- Biological Science
- California State University, Fullerton
- mtolmasky@full erton.edu
I'm a member of
- Lab website (biology.fullerton.edu)
Publications: see http://biology.fullerton.edu/mtolmasky/publicationsMT.html
Virulence (or pathogenicity) is the ability of a bacterium to cause disease, and the product(s) or mechanism(s) that contribute to the virulence of the bacterium are known as virulence factors.
To establish a successful infection, a bacterial pathogen must overcome the adverse conditions posed by both, the host's defense mechanisms as well as therapeutic treatments. The natural defenses include specific and non-specific mechanisms directed to kill or deprive bacteria of necessary nutrients. In addition to these natural mechanisms, the presence of antibacterial agents, as a result of medical treatment, contributes to the hostility of the environment where the infecting bacteria must survive. Several virulence factors help the bacterium to overcome the hostile environment found in the host's body. Understanding different aspects of these virulence factors may lead to the development of novel treatments to combat bacterial diseases. We study the genetics and molecular biology of some virulence factors in various pathogens.
Positions & Honors
2002 – Faculty Research Award, CSUPERB