- Assistant Professor
- California State University, Long Beach
- vnaraya2@csu lb.edu
My research work involves investigating the role of apolipoprotein E (apoE) the plasma cholesterol transport protein in relation to cardiovascular disease. In addition, in view of the critical role of cholesterol in the central nervous system, we evaluate the significance of apoE in the brain, especially in neurodegenerative diseases such as Alzheimer’s disease (AD). The following are the main projects in my group: (i) examine the structure-function relationships of apoE using state-of-the-art fluorescence and other biophysical approaches, (ii) evaluate use of HDL as a drug delivery and targeting vehicle, (iii) evaluate the effect of oxidative stress and second hand smoke exposure on the structure and function of apoE in vivo with parallel in vitro studies, (iv) investigate the role of apoE isoforms in the amyloidogenesis process in Alzheimer’s disease and cerebrovascular amyloidosis at the molecular and cellular levels, and, (v) study the role of apoE in cholesterol transport and metabolism at the neurovascular junction.